Recommendation Against Inhaled Flu Vaccine is Good—for Now—Pitt and CMU Analysis Finds

PITTSBURGH, April 24, 2017 – Recent federal recommendations against offering the inhaled nasal influenza vaccine due to lack of effectiveness could lead to more flu illness in the U.S. if the inhaled vaccine becomes effective again or if not having the choice of the needle-less vaccine substantially reduces immunization rates, according to a new analysis led by University of Pittsburgh School of Medicine scientists.



“The CDC is being appropriately cautious and doing the right thing based on available data,” said lead author Kenneth J. Smith, M.D., M.S., professor of medicine and clinical and translational science in Pitt’s School of Medicine. “However, our study finds that it would take only relatively small changes to tip the scales back in favor of offering the LAIV, so close monitoring is very important.”

The Pittsburgh Vaccination Research Group (PittVax) is one of a few sites across the U.S. that track flu in patients who received and did not receive the annual flu vaccine. The data they collect is shared with the CDC’s Advisory Committee on Immunization Practices and led to the CDC’s recommendation against LAIV last year after data from the two previous flu seasons showed it to be ineffective at preventing influenza A, which is typically the most common strain. In the past, the LAIV was a common vaccine offered to children 2 to 8 years old.

Under current conditions, only offering the needle-delivered flu vaccine results in 20.9 percent of children ages 2 to 8 getting the flu, compared with 23.5 percent if both the needle and nasal vaccine are offered.

However, if the LAIV effectiveness improves and can prevent flu in more than 63 percent of the people who get it, then it once again becomes beneficial to offer both forms of vaccination.

“Interestingly, there has been no decrease in LAIV effectiveness in other countries, and we’re still unsure why this is,” said ...

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