The Hormone Oxytocin is Being Tested for Treatment of PTSD and Alcohol Abuse

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Nightmares. Obsessive thoughts. Avoiding particular places. Sudden outbursts. Fearing you’re in danger. Survivor guilt.

These experiences – manifestations of post-traumatic stress disorder (PTSD) – are part of life for up to 1 in 3 U.S. combat veterans and active military personnel. That’s more than triple the prevalence of PTSD in the population at large. About two-thirds of those with PTSD struggle with alcohol abuse.

A new trial may hold new hope for these military personnel through treatment with oxytocin, sometimes referred to as the “love hormone.”

A Shift in Thinking

It’s no surprise that the threat or actuality of battle takes a psychological toll. What is surprising, are changes that Jennifer Mitchell, PhD, an associate professor of neurology in the UCSF School of Medicine, has found in the U.S. military’s attitude toward the condition, and its willingness to experiment in order to help troubled soldiers.

Jennifer Mitchell, PhD“It used to be that when an officer was experiencing this kind of thing, they were simply excused from the military,” said Mitchell, whose work focuses on PTSD and substance abuse. “Now they’re coming to accept that this is happening to many career personnel, and the military wants to keep these active duty people going. It’s an entirely new development philosophically.”

That shift is allowing Mitchell to test the potential of oxytocin, a hormone released during sex, childbirth and lactation as a treatment for PTSD and substance abuse among active military personnel. Oxytocin, present in both women and men, plays a role in social behavior, trust, empathy, and managing stress and anxiety. Its qualities have drawn researchers to the hormone, which is showing promise as a treatment for autism and schizophrenia.

“It helps with several conditions because they all involve similar stress responses,” said Mitchell, who has published findings about oxytocin for substance abuse. “Our thinking is that ...

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